What are the symptoms of low Homocysteine?

Rarely problematic, Could indicate excess B vitamin supplementation

What is the optimal range for Homocysteine?

The optimal range for Homocysteine is 6-9 µmol/L.

What causes high Homocysteine?

Increased cardiovascular disease risk, Cognitive decline and dementia risk, Blood clot formation, Bone weakness (osteoporosis), Stroke risk

Longevity

What is Homocysteine? Optimal Ranges & Function

Normal Range:5-15 µmol/L

Optimal Range:6-9 µmol/L

What is Homocysteine?

Homocysteine is an amino acid produced during methionine metabolism. It requires B vitamins (B6, B12, folate) for proper clearance from the blood. Elevated levels accumulate when these pathways are impaired.

Why Homocysteine Matters

Elevated homocysteine is an independent risk factor for cardiovascular disease, cognitive decline, and accelerated aging. Lower levels are strongly associated with better vascular health and longevity. It's one of the most modifiable longevity markers.

Symptoms of Low Homocysteine

Rarely problematic
Could indicate excess B vitamin supplementation

Symptoms of High Homocysteine

Increased cardiovascular disease risk
Cognitive decline and dementia risk
Blood clot formation
Bone weakness (osteoporosis)
Stroke risk

Reference Ranges

5 µmol/L15 µmol/L

Standard Lab Range

BioStack Optimal

Range Type	Minimum	Maximum	Unit
Normal Range	5	15	µmol/L
Optimal Range	6	9	µmol/L

Related Biomarkers

Vitamin B12 Folate NAD+ (Intracellular)CRP Fibrinogen Lipoprotein(a)

When to Request Additional Tests

If Your Homocysteine is High

When Homocysteine is elevated, consider testing the following markers to get a more complete picture:

Vitamin B12 — Check methylation cofactor
Folate — Check methylation cofactor

Analyze Your Homocysteine Levels

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