BioStack
    Longevity

    What is SHBG (Sex Hormone Binding Globulin)? Optimal Ranges & Function

    Normal Range:10-130 nmol/L
    Optimal Range:30-70 nmol/L

    What is SHBG (Sex Hormone Binding Globulin)?

    A protein produced by the liver that binds to sex hormones (testosterone, estradiol, DHT) and transports them through the bloodstream. It regulates how much 'free' hormone is available for tissues to use.

    Why SHBG (Sex Hormone Binding Globulin) Matters

    SHBG is a powerful longevity marker reflecting metabolic health and hormone balance. Low SHBG is strongly associated with insulin resistance, type 2 diabetes risk, and metabolic syndrome. Higher SHBG in older adults correlates with better cognitive function and reduced cardiovascular risk.

    Symptoms of Low SHBG (Sex Hormone Binding Globulin)

    • Insulin resistance
    • PCOS symptoms (women)
    • Acne and oily skin
    • Hair loss
    • Increased diabetes risk
    • Metabolic syndrome

    Symptoms of High SHBG (Sex Hormone Binding Globulin)

    • Low free testosterone symptoms
    • Fatigue and low libido
    • Muscle weakness
    • Mood changes
    • May indicate hyperthyroidism

    Reference Ranges

    10 nmol/L130 nmol/L
    30
    70
    Standard Lab Range
    BioStack Optimal
    Range TypeMinimumMaximumUnit
    Normal Range10130nmol/L
    Optimal Range3070nmol/L

    Related Biomarkers

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    Related Topics:

    shbg
    sex hormone binding globulin
    free testosterone
    metabolic health
    diabetes risk
    longevity